You shouldn’t have to do any extra configuration here. Using an anti-malware program as an on-demand scanner is a safe way to get a second opinion. Just install it and occasionally launch it to perform a scan and check for the “potentially unwanted programs” almost no one actually wants. This version of Malwarebytes shouldn’t interfere with your antivirus program at all. Instead, it only does something when you launch it and click the Scan button. In other words, it doesn’t run automatically in the background. The standard, free version of Malwarebytes Anti-Malware just functions as an on-demand scanner. But traditional advice is not to run two anti-malware programs at once. If you’re using Malwarebytes Anti-Malware, you should be running it alongside a primary antivirus program to keep your computer in tip-top security shape. But it’s intended to be used alongside an antivirus and doesn’t replace one entirely. Malwarebytes Anti-Malware is a great security tool that’s particularly effective against “potentially unwanted programs (PUPs)” and other nasty software traditional antivirus programs don’t deal with.